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  • Oncology Pipeline

    Oncology Pipeline

    Our generational commitment to driving scientific innovation is reflected by our robust pipeline of cancer cell-directed and immuno-oncology investigational therapies, as well as the smart combination of these approaches.

    Section Overview
    • Oncology Pipeline
    • HER2 TKI-zongertinib
    • DLL3/CD3 T-cell engager obrixtamig
    • B7-H6/CD3 T-cell engager
    • PD-1 inhibitor-ezabenlimab
    • CD137 FAP bispecific agonist antibody
    • SIRPα antagonist
    • VSV-GP oncolytic viruses
    • KISIMA cancer vaccine (ATP150/ATP152/ATP162, VSV-GP154 + ezabenlimab)
    • 2nd generation STING agonist
    • KRAS multi-inhibitor
  • Tumor Types in Focus

    Tumor Types in Focus

    Get an overview of different cancer types and how recent advances may affect clinical decision making and treatment of these cancers.

    Section Overview
    • Tumor Types in Focus
    • Non-small cell lung cancer
    • Small cell lung cancer
    • Gastrointestinal cancers
    • Head and neck squamous cell carcinoma
    • Glioblastoma
  • Collaborations

    Our Collaborators

    We are taking a diligent and broad approach, creating a collaborative research network to tap into a diversity of minds, which is vital in addressing some of the most challenging, but potentially most impactful, areas of cancer research.

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    • Collaborations
    • Collaborations
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    1501.1: A Phase 1, open-label study of BI 770371 (SIRPα antagonist) with or without ezabenlimab (PD-1 inhibitor) in patients with advanced solid tumors

    1501.1 A Phase 1, open-label study
    1501.1 A Phase 1, open-label study

    NCT05327946. https://clinicaltrials.gov/ct2/show/NCT05327946. Accessed September 2023.

    1. Home
    2. Oncology Pipeline
    3. SIRPα Antagonists
    4. NCT05327946 (1501-0001)
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    Pipeline compounds shown in this website are under pre-clinical and/or clinical investigation and have not been approved by regulatory authorities for commercial use in patients. Efficacy and safety have not been established and there is no guarantee that they will become commercially available for the uses under investigation.

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