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Preclinical Results

VSV-GP induces a pro-inflammatory microenvironment within infected tumors and increases T-cell infiltration1

VSV-GP induces a pro-inflammatory microenvironment within infected tumors and increases T-cell infiltration chart

VSV-GP induces a pro-inflammatory microenvironment within infected tumors, increases immune cell infiltration, and synergizes with α–PD-1

VSV-GP treatment leads to tumor remission and prolonged survival in a murine lung cancer tumor model2 
 

VSV-GP treatment leads to tumor remission and prolonged survival in a murine lung cancer tumor model charts

  • Systemic and IT virus treatment of IFNAR1−/− tumors induced strong tumor remission

  • Median survival was significantly (***P<0.001) increased in VSV-GP–treated mice
     

1.  Müller P, et al. AACR 2020. Poster 4450; 2. Schreiber LM, et al. Br J Cancer. 2019;121:647–658.